The role and structure of the multidisciplinary team in the management of advanced Parkinson’s disease with a focus on the use of levodopa–carbidopa intestinal gel
نویسندگان
چکیده
A multidisciplinary team (MDT) approach is increasingly recommended in Parkinson's disease (PD) treatment guidelines, but no standard of care exists for such an approach, and the guidelines do not provide clarification on how it should be implemented. This paper reviews evidence of MDT interventions in people with PD and provides expert clinical perspectives for an MDT approach, with a focus on advanced PD and levodopa-carbidopa intestinal gel (carbidopa-levodopa enteral suspension in the USA). The key recommendations are to enable the best possible treatment of people with PD locally by facilitating a close structured collaboration of different health care professionals working in a fixed network structure; to refer people with PD to established MDT centers in a timely manner; to establish regular meetings for the MDT enabling interdisciplinary exchange and learning; to optimize individual treatment and carefully evaluate available treatment options; to ensure treatment decisions are agreed jointly between people with PD, their caregivers, family, and health care professional; and to include specialists outside of neurology from adjuvant medical departments as necessary when implementing advanced therapies.
منابع مشابه
Use of advanced therapies for Parkinson's disease in Norway.
BACKGROUND Many patients with Parkinson’s disease with severe motor fluctuations benefit from advanced therapies – either deep brain stimulation or continuous infusion therapy with levodopa-carbidopa intestinal gel or apomorphine. In Norway, deep brain stimulation is provided as a shared national or multi-regional service. The treatment is currently available at Oslo University Hospital and St....
متن کاملInterim results from an international, open-label study of levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease: efficacy results by country
Interim results from an international, open-label study of levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease: efficacy results by country P. Odin1,2, A.J. Espay3, A.D. Vanagunas4, R.A. Hauser5, H.H. Fernandez6, D.G. Standaert7, W.Z. Robieson8, Y. Pritchett8, K.L. Widnell8, K. Chatamra8, J. Benesh8, R.A. Lenz8 1Klinikum-Bremerhaven, Bremerhaven, Germany, 2Skane Univ...
متن کاملNeuropathy in Parkinson’s Disease Patients with Intestinal Levodopa Infusion versus Oral Drugs
BACKGROUND Severe polyneuropathy has been observed in a number of patients treated for Parkinson's disease with Levodopa/Carbidopa intestinal gel infusion. This may reflect a rare individual complication or a systematic side effect. OBJECTIVE To investigate whether peripheral nerve function differed between patients with oral treatment versus Levodopa/Carbidopa intestinal gel infusion. METH...
متن کاملEffect of levodopa‐carbidopa intestinal gel on dyskinesia in advanced Parkinson's disease patients
OBJECTIVE The purpose of this study was to assess the effect of levodopa-carbidopa intestinal gel (carbidopa-levodopa enteral suspension) in advanced Parkinson's disease patients with troublesome dyskinesia. METHODS Post hoc analyses of patient data from a 12-week, randomized, double-blind study and a 54-week open-label study were performed. Efficacy was assessed in the subgroup of patients d...
متن کاملDevelopment of new levodopa treatment strategies in Parkinson’s disease—from bedside to bench to bedside
This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson's disease, have been developed in colla...
متن کامل